Mu myaka ya za 90, Pfizer yafashe iya mbere mu guteza imbere no gutondekanya ibicuruzwa bya mbere ku isi bitari gelatine capsule shell, ibikoresho fatizo nyamukuru bikaba ari selile ester "hydroxypropyl methyl selulose" ikomoka ku bimera.Kuberako ubu bwoko bushya bwa capsule butarimo ibikomoka ku nyamaswa, birashimwa ninganda nka "capsule y ibihingwa".Kugeza ubu, nubwo igurishwa rya capsules y’ibihingwa ku isoko mpuzamahanga rya capsule ritari hejuru, umuvuduko w’iterambere rirakomeye cyane, hamwe n’iterambere ry’isoko ryagutse.
　　
"Hamwe n'iterambere ry'ubumenyi n'ikoranabuhanga n'ubuvuzi n'ubumenyi bifitanye isano, akamaro k’ibicuruzwa biva mu miti mu gukora imiti y’imiti byamenyekanye buhoro buhoro, kandi aho farumasi igenda yiyongera."Ouyang Jingfeng, umushakashatsi wungirije mu Ishuri Rikuru ry’Ubuvuzi ry’Ubushinwa mu Bushinwa, yagaragaje ko imiti y’imiti itagaragaza gusa ireme ry’imiti mishya ndetse n’imyiteguro mishya y’imiti ku buryo bugaragara, ariko kandi ifasha no kwitegura gushinga, gutuza, kwikemurira ibibazo. , kongera solubilize, kwagura kurekura, kurekurwa kurambye, kugenzurwa kurekurwa, icyerekezo, igihe, umwanya, kwihuta-gukora, gukora neza no gukora-igihe kirekire, kandi muburyo bumwe, iterambere ryibintu byiza bishya bishobora kuganisha kumajyambere yicyiciro kinini y'imiterere ya dosiye, kuzamura ubwiza bwimibare myinshi yimiti nimyiteguro, kandi akamaro kayo karenze kure iterambere ryimiti mishya.Muburyo bwa farumasi yimiti nkibinini bya cream, ibinini, inshinge, hamwe na capsules, capsules yabaye uburyo nyamukuru bwimyanya myiteguro ikomeye yo munwa kubera bioavailable nyinshi, kuzamura umutekano wibiyobyabwenge, hamwe nigihe cyo guhagarika no kurekura ibiyobyabwenge.

Kugeza ubu, ibikoresho nyamukuru bibyara umusaruro wa capsules ni gelatine, gelatine ikorwa na hydrolysis yamagufwa yinyamanswa nimpu, kandi ni macromolecule yibinyabuzima ifite imiterere ya ternary spiral spiral, ifite biocompatibilité nziza hamwe numubiri na chimique.Nyamara, capsules ya gelatine nayo ifite aho igarukira mubikorwa, kandi guteza imbere ibikoresho bishya bya capsule ibishishwa bituruka ku nyamaswa byahindutse ahantu hashyushye mubushakashatsi buherutse gukorwa ku bicuruzwa bivura imiti.Wu Zhenghong, umwarimu muri kaminuza y’imiti y’Ubushinwa, yavuze ko kubera "indwara y’inka yasaze" mu bihugu by’Uburayi nka britain, Ubufaransa n’Ubuholandi mu myaka ya za 90 (harimo n’Ubuyapani muri Aziya, wasangaga inka zasaze zifite indwara z’inka zasaze) , abaturage bo mubihugu byiburengerazuba ntibizeraga cyane inyama zinka ninka zijyanye nibicuruzwa (gelatine nayo nimwe murimwe).Byongeye kandi, Ababuda n’ibikomoka ku bimera na bo barwanya capsules ya gelatine ikozwe mu bikoresho fatizo by’inyamaswa.Urebye ibi, amasosiyete amwe n'amwe ya capsule yo mu mahanga yatangiye kwiga ibikoresho bishya bya capsule shell ya non-gelatine nandi masoko y’inyamanswa, kandi ubwiganze bwa capsules gakondo bwatangiye guhungabana.

Kubona ibikoresho bishya byo gutegura capsules itari gelatine nicyerekezo cyiterambere cyiterambere ryibikoresho bya farumasi.Ouyang Jingfeng yagaragaje ko ibikoresho fatizo bya capsules y’ibihingwa ari hydroxypropyl methylcellulose, ibinyamisogwe byahinduwe hamwe na hydrophilique polymer ibiryo bifunga ibiryo, nka gelatine, karrageenan, amase ya xanthan n'ibindi.Hydroxypropyl methyl selulose capsules ifite ibisubizo bisa, gusenyuka hamwe na bioavailability kuri gelatin capsules, mugihe ufite ibyiza bimwe na bimwe capsules ya gelatine idafite, ariko ikoreshwa ryubu ntabwo iraguka cyane, cyane cyane kubera igiciro kinini cyibicuruzwa, ugereranije na gelatine, hydroxypropyl methyl selulose capsule ibikoresho fatizo biri hejuru, hiyongereyeho umuvuduko wa gel gahoro, bikavamo umusaruro muremure.

Ku isoko ry’imiti ku isi, capsules yibihingwa nimwe mubicuruzwa byihuta cyane.Wu Zhenghong yavuze ko ugereranije na capsules ya gelatine, capsules y'ibihingwa ifite ibyiza bigaragara bikurikira: Icya mbere, nta reaction ihuza abantu.Capsules yibihingwa ifite ubudahangarwa bukomeye kandi ntabwo byoroshye guhuza amatsinda ya aldehyde cyangwa ibindi bintu.Iya kabiri ibereye imiti yangiza amazi.Ubushuhe buri muri capsules yibihingwa bigenzurwa muri rusange hagati ya 5% na 8%, kandi ntabwo byoroshye kubyitwaramo imiti nibirimo, kandi amazi yo hepfo yemeza ko ibintu bya hygroscopique bihagaze neza.Icya gatatu nuguhuza neza nibikoresho nyamukuru bya farumasi.Imboga za capsules zifite aho zihurira neza na lactose, dextrin, krahisi, microcrystalline selulose, magnesium stearate nibindi bintu bikoreshwa cyane mu bya farumasi.Icya kane ni ukugira ibidukikije byoroheje byuzuye.Ibihingwa bya capsules bifite ibyangombwa bisabwa kubikorwa byakazi byuzuye, byaba ibisabwa mubidukikije bikora cyangwa igipimo cyatsinzwe kuri mashini, gishobora kugabanya ikiguzi cyo gukoresha.
　
　
"Ku isi, capsules y'ibihingwa iracyari mu marembera, ibigo bike cyane ni byo bishobora gutanga imiti y’imiti y’ibihingwa, kandi birakenewe ko dushimangira ubushakashatsi mu bikorwa by’umusaruro ndetse no mu zindi ngingo, ari nako byongera imbaraga mu kuzamura isoko."Ouyang Jingfeng yagaragaje ko kuri ubu, umusaruro wa capsules ya gelatine mu Bushinwa wageze ku mwanya wa mbere ku isi, mu gihe umugabane w’isoko ry’ibicuruzwa bya capsule bikiri hasi.Byongeye kandi, kubera ko ihame ryibikorwa byo gukora capsules ridahindutse mumyaka irenga ijana, kandi guhora utezimbere ibikoresho byateguwe ukurikije uburyo bwo gukora gelatine, uburyo bwo gukoresha inzira nibikoresho byo gutegura capsules ya gelatine kugirango utegure igihingwa capsules yahindutse intumbero yubushakashatsi, burimo ubushakashatsi bwihariye bwibintu nkibikorwa byijimye, imiterere ya rheologiya na viscoelasticitike yibikoresho.
　　

Nubwo bidashoboka ko capsules yibihingwa isimbuza ubwiganze bwa capati ya gelatine gakondo, capsules yibihingwa bifite inyungu zigaragara mumarushanwa mugutegura imiti gakondo yubushinwa, gutegura ibinyabuzima nibiribwa bikora.Zhang Youde, injeniyeri mukuru mu Ishuri Rikuru ry’Ubumenyi n’Ubwubatsi mu Ishuri Rikuru ry’ikoranabuhanga rya Beijing, yizera ko hamwe n’uko abantu basobanukiwe byimazeyo ibihingwa by’ibihingwa ndetse n’imihindagurikire y’ibitekerezo by’ibiyobyabwenge by’abaturage, isoko ry’ibikomoka ku bimera biziyongera vuba.